The Aryal Laboratory
Overview
The Aryal lab specializes in Mass Spectrometry based approaches to investigate the underlying mechanisms of senescence and aging, at both the cellular and organism levels. Our lab is interested in understanding how the changes in the the proteome, as well as the dynamic changes in protein post-translational modifications, contribute to aging and aging associated diseases, such as Cancer, Neurodegenerative diseases, Insulin Resistance and Nonalcoholic Fatty Liver Disease (NAFLD)
Recent Publications
Mohallem, R., and Aryal, U. K. (2024) Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence. Mol Cell Proteomics 23, 100715 [Mol Cell Proteomics]
Kim, S. Q., et al. (2022). Global landscape of protein complexes in postprandial-state livers from diet-induced obese and lean mice. Biochemical and Biophysical Research Communications. [BBRC]
Kim, S. Q., et al. (2022). Multi-Omics Approach Reveals Dysregulation of Protein Phosphorylation Correlated with Lipid Metabolism in Mouse Non-Alcoholic Fatty Liver. Cells 11(7): 1172. [Cells]
Mohallem, R., and Aryal, U.K. (2021). Quantitative Proteomics and Phosphoproteomics Reveal TNF-α-Mediated Protein Functions in Hepatocytes. Molecules 26, 5472. [Molecules]
Mohallem, R. and U. K. Aryal (2020). Regulators of TNFα mediated insulin resistance elucidated by quantitative proteomics. Scientific Reports 10(1): 20878. [Scientific Reports]